Curriculum Vitae (abridged) Salvador Harguindey MD., Ph D.

Salvador Harguindey MD., PhD

Director, Institute for Clinical Biology and Metabolism

Vice President, International Society for Proton Dynamics of Cancer (www.ispdc.eu)

Medical Oncology, Neurodegenerative Diseases and Endocrinology

Born in 1946, in Madrid, Spain.

Languages: Spanish, English (advanced), French (medium).

Medical Education and Career Experience

Graduation as Medical Doctor (MD) from The University of Navarre Medical School, Spain, in 1969, at the age of 22. (Youngest student to obtain his title to that date in the University of Navarre Medical School).

Degree Title, University of Navarre, Pamplona, Spain, 1969. Calification: Honours.

ECFMG (Educational Council for Foreign Medical Graduates). Passed with an 80% score.

Specialty in Medical Endocrinology, Royal Infirmary Hospital, University of Edinburgh, Scotland and Department of Endocrinology, Eugene Taldmage Memorial Hospital, Augusta, Georgia, USA,1977.

Specialty in Medical Oncology (Roswell Park Memorial Institute, Buffalo, New York,1981. Recognized in Spain by the Ministery of Health, 1985.

Previously held positions

Medical Internship in Internal Medicine, University Clinic, Pamplona, Spain (1969-1970).

Senior Medical Resident (Registrar) in Medical Endocrinology at The Royal Infirmary Hospital, University of Edinburgh, Scotland (1970-1973).

Resident, Intensive Care Unit, Royal Infirmary Hospital, Edinburgh, Scotland 1973-1974.

Medical Research Fellow in Endocrinology at The Medical College of Georgia, Augusta, Georgia, USA (1973-1976).

Medical Resident in Medical Oncology (Roswell Park Memorial Institute, Buffalo, New York (1976-1979).

Clinical Research Associate in Medical Oncology, Department of Thoracic Surgery and Oncology, (Roswell Park Memorial Institute, Buffalo, New York (1979-1982).

Clinical Research Associate in Medical Oncology, University Clinic of Navarre, Pamplona, Spain (1982-1986).

Medical Oncologist, Oncology Service, Clinica La Esperanza and Policlinica San Jose, Vitoria, Spain (1986-2001).

Medical Oncologist, Clínica La Salud, Vitoria, Spain, 2001-2007.

Associate Researcher of the Department of Pharmacological Therapeutics, University of The Basque Country, Vitoria, Spain (1995-to present)

Senior Research Associate, Biotechnology Institute “I mas D”, Vitoria, Spain (1998 to present).

Research Associate, Instituto del Metabolismo Celular, Tenerife, The Canary Islands, Spain (2006-2008)

Director, Institute for Clinical Biology and Metabolism, Vitoria, Spain (2008 to present).

Honorary Professor, University of Alcala de Henares, Madrid, 2012-present.

A.Ph. D. Thesis

Harguindey S. The pH in the Etiopathogenesis and Treatment of Cancer. Ph. D. Thesis, University of the Basque Country, Bilbao, Spain, (1990) (Honors, Cum Laude).

Memberships (past and present).

American Society of Clinical Oncology
European Society of Medical Oncology
Spanish Society of Cancer Research (ASEICA).
USA Association for Transpersonal Psychology (ATP).
Spanish Association of Transpersonal Psychology (ATRE)

Spanish Society for Transpersonal Psychology (SEPT)

New York Academy of Sciences
Vice-President, International Society for Proton Dynamics in Cancer (www.ispdc.eu)

Previous Teaching
Radioimmunoassay Techniques (Prolacin asays), 1974-1975, Faculty of Medicine of Georgia Medical School, Augusta, Georgia, USA; 1974-1975.
Assistant Professor of Fourth Year medical students practical teaching, Faculty of Medicine of Georgia Medical School, Augusta, Georgia, USA; 1973-1976.
Clinical Instructor in Medicine, New York State School of Medicine at Buffalo, USA; 1976-1977.
Teacher of different courses and seminars for preparation for Medical Degrees and Doctoral Thesis, University Clinic, Pamplona, Spain, 1984-1985.

Research grants and projects management

-  Grant/Scholarship in Diabetes Research, Servier Laboratories, Department of Diabetes, Royal Infirmary Hospital, University of Edinburgh, Scotland, 1971-1974.

-  Institutional Research Grants CA-5834 and CA.09108 of the National Institutes of Health, Maryland, USA, at Roswell Park Memorial Institute, Buffalo, New York, USA, 1980-1981.

-  Clinical Research Grant of The American Cancer Society, at Roswell Park Memorial Institute, Buffalo, New York, USA, 1980.

-  Research Grant of the Scientific and Technical Research Commision (CAICYT)  No. 1801/82., date: 30/11/1983. 

-  Research Grant of the Scientific and Technical Research Commision (CAICYT)  No. 1567/82., date: 30/11/1983.

-  Clinical Research Grant of the Scientific and Technical Research Commision (CAICYT)  No.  467/84.

-  Clinical Trial Grant, Roche Pharmaceuticals, University Clinic, Pamplona, Spain, 1984..

Main publications - selected from more than a 140 original papers

(Abstracts and Congress Presentations not included).

- First or Senior Author author of more than one hundred peer-reviewed scientific publications in original Cancer Research and Neurodegenerative Diseases mainly dealing with the personal and singlehanded creation of a new integral model of malignant diseases and neurodegenerative diseases such as Alzheimer Disease based upon the microenvironmental dynamics of the hydrogen ion and membrane-bound proton transporters and their inhibition and/or stimulation.

Harguindey S., R. C. Kolbeck, and E. D. Bransome Jr: Ureterosig­moidostomy and cancer: new observations. Ann. Intern. Med., 83: 833, 1975.

Harguindey, S., and Kolbeck R. C. Cancer - a generalization. American Laboratory, August, 1976.

Harguindey S., W. A. Speir, R. C. Kolbeck, and E. D. Bransome Jr. Alkalotic disequilibrium in patients with solid tumors: rediscovery of an old finding. Eur. J. Cancer., 13: 793‑800, 1977.

Harguindey S., and M. J. Gillis: Experimental and human cancer, pH, and spontaneous regressions. American Lab., 1: 91‑92, 1979.

Harguindey S., E. S. Henderson, and C. Naher: Effect of systemic acidification of mice with sarcoma 180. Cancer Res., 39: 4364‑ 4371, 1979.

Harguindey, S., and M. L. Gillis: Evolution and cancer: possible relationships to changes in environmental hydrogen ion concentra­tion. J. Theor. Biol., 86: 487‑492, 1980.

Harguindey S. Hierachical organization, integrations in biology and cancer, balance loss, and a question on modernism. Med. Hypotheses, 7: 1123-1132, 1981.

Takita H, Edgerton F, Marabella P, Conway D, Harguindey S. Platinum-based combination chemotherapy in non-small cell lung carcinoma. Cancer 48(7): 1528-30, 1981.

Harguindey, S. Hydrogen ion dynamics and cancer: an appraisal. Med. Pediatr. Oncol., 10: 217‑236, 1982.

Harguindey, S. Spontaneous Regression of Cancer: an integrated vision of possible mediating mechanisms. Neoplasia (Madrid): 2(2) April-June, 1985.

Poydock ME, Harguindey S, Hart T, Takita H, Kelly D. Mitogenic inhibition and effect on survival of mice bearing L1210 leukemia using a combination of dehydroascorbic acid and hydroxycobalamin. Am J Cliin Oncol., 8(3): 266-9, 1985.

Calvo FA, Pastor MA, Dy C, Alegría E, Antón Aparicio L,  Gil A, Harguindey S, Zubieta JL, Martinez Lage M. Intra-arterial and intravenous chemotherapy for the treatment of malignant glioma. Preliminary results. Am J Clin Oncol., 8(3):200-9, 1985.

Calvo FA, Harguindey S, Antón Aparicio LM, Dy C, Gil A, Rocha E. Urokinase and combination chemotherapy for treatment pf small cell carcinoma of the lung. Cancer Treatment Symposia 2: 105-108, 1985.

Harguindey S. Spontaneous regression of cancer: an integral vision of possible mediating mechanisms. Neoplasia (Madrid) 2: 87-90, 1985.

Harguindey S, Antón-Aparicio LM, Monge A, Poydock ME. Resistance to Ascorbic Acid and efectivity of dehydroascorbica acid (DHA) in animal and human malignancies.  Revisions on Cellular Biology (Spain), Suppl. 1, pp. 30, 1986.

Harguindey S, Antón-Aparicio LM. Enlarging Warburg´s theory: The Hydrogen ion as a leading environmental factor in human carcinogenesis and cancer prevention. Revisions on Cellular Biology (Spain), Suppl. 1, pp. 302, 1986.

Gonzalez Falcó J, Madamba AM, de la Fuente F, Anton Aparicio L,  Jurado Chacón M, Harguindey S. Cervical mosaic and an integrated pathophysiologica approach to early cervical neoplasia. J. Biol Resp. Modifiers 6(5): 473-83, 1987.

Antón-Aparicio L, Harguindey S. Research en the hormone-dependency of breast cáncer: pathways and progress. Oncologia (Madrid) 12: 25-44, 1988.

Harguindey S. Direct consquences of pH levations en basic cell behaviour. IN “Plasma Menbrane Oxidoreductaces in Control of Animal and Plant Growth. NATO  ASI Series, Series A. Life Sciences 157, 1988.

Dy C, Calvo FA, Mindán JP, Aparicio LA, Algarra SM, Gil A, González F, Harguindey S. Undifferentiated epithelial-rich invasive malignant thymoma: complete response to cisplatin, vinblastine and bleomycin therapy. J Clin Oncol., 6(3):536-42, 1988.

Harguindey S. Possible exploitation of an H⁺‑related mechanism in the treatment of breast and colon tumors: a new approach to the adjuvant treatment of cancer. In: “Plasma oxidoreductases in control of animal and plant growth” (F. L. Crane, D. J. Morré, and H. Löw, Eds.) Plenum Press, New York‑London, 415‑418, 1988.

 Harguindey S. Integrated etiopathogenesis of cancer of mucosal surfaces with emphasis on the digestive tract. J. Biol. Resp. Mod., 8: 1‑10, 1989.

Antón-Aparicio L, Harguindey S, Verea Hernando H. Superoxide dismutase as blocker of lung toxicity by bleomycin. Neoplasia, 6: 215-221, 1989.

Harguindey, S., E. J. Cragoe Jr., and R. García Cañero: pH effects on tumors growth and an H⁺ and Na⁺/H⁺ antiport system-related approach to the treatment of at least ras p21 and v-mos dependent tumors. Cancer Chem. Pharmacol., 24:(Suppl 2), s86, 1989.

García Cañero. R, Guerra MA, Harguindey S, Cragoe EJ Jr. Regulation of intracelular pH and cell growth. The role of the Na:H antiporter. Oncologia (Madrid), 14(7): 316-318, 1991.

Harguindey, S., and E. J. Cragoe: The Na⁺/H⁺ antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism. Med. Hypotheses, 39: 229‑237, 1992.

Harguindey, S. Homeostasis, diabetes and cancer. Ann. Int. Med., 10: 611‑616, 1993.

Harguindey, S. The unitary strategy of cancer cells: carbohydrate metabolism (first of three parts). Ann. Int. Med., 5: 247-254, 1994.

Harguindey, S. The unitary strategy of cancer cells: the hydrogen ion as a multidimensional unitary factor and carbohydrate metabolism. (Second of three parts). Ann. Int. Med., 2: 299-303, 1994.

Harguindey, S. The unitary strategy of cancer cells: fat and pro­tein metabolism. Conclusions (third of three parts) Ann. Int. Med., 2: 351-358, 1994.

Harguindey S, Galdós I, Takita H. Lung cancer as a scar tumor: report of a case and possible etiopathogenic mechanisms. Ann Int Med., 2: 285-7, 1994.

Harguindey S, Pedraz JL, García Cañero R, Katin M. Edelfosine, Apoptosis, MDR and Na⁺/H⁺ exchanger: induction mechanisms and treatment implications. Apoptosis, 5: 87-9, 2000.

Harguindey S. Towards a Quintaessential Approach to Crisis and Disease: The Crossroads-Crossfire-Turning Point-Conflict Theory. Internat. J. Transpersonal Studies, 19: 141-161, 2000.

Harguindey S. Integrating fields of cancer research through pivotal mechanisms and common pathways:  A unifying and creative overview. Med. Hypotheses, 58: 6; 444-452, 2002.

         

Harguindey S, Orive G, Pedraz JL. Multidisciplinary integration of oncology subfields mediated turning-point mechanisms and shared intracellular pathways: etiopathogenesis to treatment. Oncologia, 25(7): 295-316, 2002.

Harguindey S, Orive G, Pedraz JL, Bello G, Arranz Jl, Samaniego JM. Apparent cure of a case of metastatic ovarian carcinoma after long-term treatment with Na⁺/H⁺ antiporter inhibitors. Oncologia, 25(10): 62-66, 2002.

Harguindey S, Orive G, Pedraz JL. Multidisciplinary integration of oncology subfields mediated through turning-point mechanisms and shared intracellular pathways: etiopathogenesis to treatment. Oncologia 25(7): 295-316, 2002.

Harguindey S, Orive G, Pedraz JL, Bello G, Arranz Jl, Samaniego JM. Apparent cure of a case of metastatic ovarian carcinoma after long-term treatment with the Na⁺/H⁺ antiporter inhibitor amiloride. Oncologia, 25(10): 62-66, 2002.

Orive G., Reshkin S., Harguindey S., Pedraz, JL. Implicaciones del ion hidrógeno y el antiportador Na⁺/H⁺ en la angiogénesis y antiangiogénesis tumoral. Oncología, 25: 10; 438-451, 2002.

Harguindey, S. From Transpersonal Psychology to Integral Psychology. Journal of The Spanish Association for Transpersonal Psychology, No 1, pp 9-18, 2002.

Harguindey S, Cragoe EJ Jr. The Na⁺/H⁺  antiporter in oncology in the light of the spontaneous regression of cancer and cell metabolism. Med Hypotheses, 39(3): 229-37, 2003.

B. Harguindey S. Erratum to “Integrating fields of cancer research through pivotal mechanisms and common pathways:  A unifying and creative overview. Med. Hypotheses, 61(2): 318-319, 2003.  

Galdós Ayala J, Basterra Romo G, Martínez Blázquez C, Díaz de Otazu R, Alvarez Rubio M, Katin M, Harguindey S. Duodenal carcinoid tumor and esophageal carcinoma associated to a high chronic intake of sodium bicarbonate: possible pathophysiological mechanisms. Oncologia, 26: 53-57, 2003.

Orive G., Reshkin S., Harguindey S., Pedraz, JL.  Hydrogen ion dynamics and the Na⁺/H⁺ exchanger in cancer angiogenesis and antiangiogenesis. Brit. J. Cancer, 89: 1395-1399, 2003.

Harguindey S. Apoptosis and antiapoptosis in cancer, Alzheimer and neurodegenerative processes. A dialectics of opposites?  New range of possibilities and potential dangers. Oncologia, 27(10): 579-589, 2004.

Harguindey S. Apoptosis and antiapoptosis in cancer and neurodegenerative processes as metabolic opposites. Therapeutic possibilities. Geriatrika, 21(2):38-47, 2005.

Harguindey S, Orive G, Anitua E, Arranz JL, Cacabelos R, Díaz de Otazu R, Meléndez Hevia E. Hacia un nuevo enfoque integrado del tratamiento de las enfermedades neurodegenerativas (ENDs): de la etiopatogenia al tratamiento. El síndrome de deficiencia de factores tróficos. Gen T, January, 2008.

   

Harguindey S, et al. Scientific Manifesto of the International Society for Proton Transport in Cancer. Gen T, June, 2010.

Huber, V, Harguindey S, et al. Proton dynamics of Cancer. J. Translat. Medicine,  8:57-60, 2010 (http://www.translational-medicine.com/content/8/1/57).

Harguindey S, Polo Orozco JD, Cuenca M, Cano Fernandez M and Arranz JL. New and powerful NHE1 inhibitors as potential anticancer drugs in bedside oncology: a prospective program of preclinical studies in cats and dogs with spontaneous malignant tumors. The Fourth Annual Meeting of the International Society of Proton Dynamics in Cancer. Munich. Front. Pharmacol., September 2014,

(1)                       Reviews

Harguindey S, Pedraz JL, García Cañero R., Pérez de Diego J, Cragoe, EJ Jr. Hydrogen ion-dependent oncogenesis and parallel new avenues to cancer prevention and treatment using a H⁺-mediated unifying approach: pH-related and pH-unrelated mechanisms. Critical Rev. Oncogenesis, 6(1): 1-33, 1995.

Harguindey S, Orive G, Pedraz JL, Paradiso, Reshkin SJ. The role of pH dynamics and the Na⁺/H⁺ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin-one single nature. Bioch. Biophys. Acta Revs. Cancer, 1756: 1-24, 2005.

Harguindey S,  Reshkin SR, Orive G, Arranz JL, Anitua E. Growth and trophic factors and the pH-Na⁺/H⁺ antiporter in apoptosis in Alzheimer´s disease, other neurodegenerative processes and cancer. New therapeutic possibilities and potential dangers. Curr. Alzheimer Res., 4: 53-67, 2007.

Harguindey S, Orive G, Anitua E, Cacabelos R, Meléndez Hevia E, Díaz de Otazu R, Arranz  JL. An integral approach to the etiopathogeneis of Human Neurodegenerative Diseases (HNNDs) and Cancer. Possible Therapeutic Consequences within the frame of The Trophic Factor Withdrawal Syrndrome (TFGS). Neuropsych. Dis & Treat., (solicited review) 4(6): 1073-1087, 2008.

Harguindey S., Arranz JL, Wahl ML, Orive G., Reshkin SJ. Proton Transport Inhibitors as Potentially Selective Anticancer Drugs. Anticancer Res., 29: 2127-2136, 2009.

Milosavljevic N, Blanchard A, Wahl ML, Harguindey S, Poet M, Counillon L, Rauch C. Teaching new dogs old tricks: membrane biophysical properties in drug delivery and resistance. Recent Pat. Anticancer Drug Discov., 6(3):334-46, 2011 (doi: 10.2174/157489211796957829.

Daniel Ch, Bell Ch, Burton Ch, Harguindey S, Reshkin SJ, Rauch C. The role of proton dynamics in the development and maintenance of multidrug resistance in cancer. Bioch. Biophys.Acta (BBA)-Molecular Basis of Disease, 1832(5), 606-617.

01/2013; doi:10.1016/j.bbadis.2013.01.020.

Reshkin SJ, Cardone RA, Harguindey S.  Na+-H+ exchanger, pH regulation and cancer. Recent Pat. Anticancer Drug Discov., 1; 8(1): 85-99, 2013.

Harguindey S, Arranz JL, Polo Orozco JD, Rauch C, Fais S, Cardone RA, Reshkin SJ.     Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs - an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J. Translat. Med. 11: 282, 2013 (http://www.translational-medicine. com/content/11/1/282)

Alfarouk KO, Verduczo D, Rauch C, Muddathir AK, Bashir AHH,  Ibrahim ME, Reshkin SR, Harguindey S. Glycolysis, tumor growth and dissemination. A new pH-based etiopathogenic and therapeutic integral approach to an old cancer question. Cancer Met. Revs., (submitted for publication).

Fais S, Harguindey S, plus other 15 members of the International Society  for Proton Transport in cancer. “Implication of proton channels and exchangers in cancer. Bioch. Biophys Acta (BBA). (Commissioned) (In preparation).

Invited to author book chapters (commissioned)

Harguindey  S. Pituitary tumor and galactorrhea.  In. “The Pituitary: a current review”. Allen MB, Mahesh V (Eds.). Academic Press, New York/San Francisco, 1977.

Harguindey, S. Use of Na⁺/H⁺ antiporter inhibitors as a novel approach to cancer treatment. In: Amiloride and its analogs: unique cation transport inhibitors. (E. J. Cragoe Jr., Th. R. Kleyman, and L. Simchowitz, Eds). VCH Publishers Inc., New York, NY, 317‑334, 1992.

Rauch C, Blanchard A, Wood E, Dillon E, Wahl ML, Harguindey S. Cell Membranes. Cytosolic pH and Drug Transport in Cancer and MDR: Physics, Biochemistry and Molecular Biology. In: Multiple Drug Resistance. (Eds: Agoston Meszaros and Gusztav Balogh, 2009 Nova Science Publishers, Inc. Chapter 3, 2009.

Harguindey S. From Transpersonal to Integral Psychology: a creative review. ATRE Journal (Spanish Association for Transpersonal Psychology),  1: 9-18, 2003.

b)                                               Scientific Directorships

Scientific Director, Congress on “Investigation on the Etiopathogenesis, Metabolism and Integrated Treatment of Cancer”, Baracaldo, Spain, September 22-23, 2001.

Director and main organizer of “The First International Symposium for Proton Dynamics of Cancer”, Ramon Areces Foundation, Madrid, Spain, April, 2009. (www.ispdc.eu).

Co-Founder and Former Vice-President of the International Society for Proton Dynamics of Cancer  (ISPDC) (www.ispdc.eu).

Honorary Vice-President of the International Society for Proton Dynamics of Cancer. 

***INVITED SPEAKER IN DIFFERENT NATIONAL AND INTERNATIONAL CONFERENCES IN CANCER RESEARCH, METABOLISM AND TRANSPERSONAL PSYCHOLOGY  (list upon request)

Other activities and interests

Novels (all published in Spanish)

“The Crib of Don Quixote”, Editorial Helios, Madrid, 1981.

“The sons of Hippocrates”, Editorial Luz Pradera, 1987.

“The Son of Don Quixote”, Editorial Luz Pradera, 2006.

“The Resurrection of Peter Pan”, Ediciones La Llave, Barcelona, Spain, May 2010.

“A Conversation in the Heavenly Skies”” (in press) Editorial Luz Pradera, 2014.

Published essays  (in Spanish)

- “A New Vision of Life and Politics: walking towards Eden” (715 pages). Editorial Luz Pradera 1999, Spain.

- “One Wisdom For All Times”, Ediciones La Llave, 2008.

- Co-editor of “Spirituality in Politics for the XXI Century” (Multiauthorship essay book) Editorial Kairós, 2011

- Hacia un enfoque quintaesencial de las crisis y de las enfermedades. La teoría de las crisis y los conflictos, puntos de inflexión y cruces de caminos (CCPC). Capítulo en el libro “Krisis” (multiauthor book) (Editorial Kairós, Barcelona), 2010.

- Psychology and Religion in the film Avatar. “What eyes do not see (In English). (In the blog: Salvadorharguindey.blogspot.com. More than 24.000 Internet entries.

- Psicología y religión en “Avatar”. Lo que los ojos no ven. Blog: Salvadorharguindey.blogspot.com. More than 24.000 Internet entries.

Creatividad, vocación y envidia en la medicina, la ciencia y la vida, Gen T, Diciembre 2012, pp. 1-12.

The Spirit of Politics. Journal of Integral Studies (California, USA, June, 2000).

Towards a universal, integral and peaceful solution for social and political conflicts from a post-conventional perspective. Journal of Integral Studies (California, USA, October, 2000).

Honorary Certificate of Merits of the International Society for Proton Dynamics in Cancer for being the Co-Founder of the Society, Munich, Germany, 11 October, 2013.

Further activities and interests

- Private aviation pilot, certified in EEUU and Spain.

- Author of more than 200 articles in different Spanish newspapers.

-  Guest Speaker at different National and European Hospitals and Universities on Clinical   Cancer Research.

-  Invited speaker to different TV programs on scientific and literary subjects in TVE2, Telemadrid and Basque Country EITB2 TV stations.

- Special interest in the Numinous and original aspects of creativity in Science, Transpersonal Psychology, Interethnic politics, Stages of Conscience and Moral values.

- Scriptwriting. Author or the Movie Script “Tadeo”